Organic Chemistry special-IV (Bioorganic and Medicinal Chemistry)
Drug Design - Introduction, historical development, factors affecting development of new drugs, concept of
lead compounds and its modification.
Concepts of prodrugs and soft drugs; Chemical and physicochemical parameters in drug design.
Drug metabolism – introduction, biological transformation like oxidation, reduction, hydrolysis and
conjugation.
Structure based drug design – introduction and process; Molecular modelling using computers –
introduction and uses.
Enzyme Inhibitors – design, competitive inhibitors, active site directed irreversible inhibitors, suicide
enzyme inactivators.
Medicinal Chemistry - Introduction, general mode of action, synthesis and medicinal uses of important drugs in the following
categories.
Antipyretic analgesics (paracetamol, aspirin), Antineoplastic (Methotrexate, Fluorouracil), antimalarials
(chloroquine, pyrimethamine), antitubercular (Isoniazid, ethambutol), antihelmintic (albendazole,
thiabendazole), and sulfa drugs (sulfanilamide, dapsone).